Scientists at the University of Sydney have uncovered a malfunctioning version of the SOD1 protein that clumps inside brain ...

Groundbreaking research by Sydney University found a new brain protein involved in Parkinson’s disease and a way to modify it ...

A newly discovered brain protein linked to Parkinson’s offers hope for targeted therapies that could slow or prevent disease ...

Groundbreaking research by the University of Sydney has identified a new brain protein involved in the development of ...

The disease, which is caused by mutations in the SOD1 gene, accounts for approximately 10% to 20% of genetic ALS cases and 1% to 2% of sporadic ALS cases, according to the ALS Association. 7.

Tofersen (BIIB067) is an ASO that is under investigation for the treatment of ALS caused by SOD1 mutations. Tofersen has been designed to mediate RNase H–dependent degradation of SOD1 mRNA to ...

Using the misfolded SOD1 antibody C4F6, Bosco discovered misfolded SOD1 in four out of nine sporadic ALS cases. The work suggests that at least some ALS cases manifest deformed SOD1, even though the ...

The decision on the SOD1 ALS program does not impact Voyager’s other gene therapy programs; the Company continues to expect IND filings in 2025 from Neurocrine Biosciences for the program in ...

SOD1, which is mutated in one-fifth of people with familial amyotrophic lateral sclerosis, forms aggregates in those people and in animal models of the disease. In a paper published online this week ...